Copper ability to induce premature senescence in human fibroblasts
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چکیده
منابع مشابه
Mitoxantrone ability to induce premature senescence in human dental pulp stem cells and human dermal fibroblasts.
UNLABELLED In this study we assessed the effects of the frequently used chemotherapeutic agent mitoxantrone (MTX) on dental pulp stem cells (DPSCs) and compared it with the response of human dermal fibroblasts (HDFs). DPSCs are valuable source of mesenchymal stem cells which may be extremely useful in a number of clinical applications. It is evident that both normal and tumor cells are being af...
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TO THE EDITOR Mitochondrial uncoupling, an increased permeability of the inner membrane to protons not coupled to ATP synthesis, dissipates mitochondrial membrane potential. Mild mitochondrial uncoupling is believed to prolong lifespan of certain model organisms by reducing the production of reactive oxygen species (ROS) and preventing oxidant damage (Brand, 2000). Indeed, long-lived Caenorhabd...
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BACKGROUND Recent studies have demonstrated that activation of autophagy increases the lifespan of organisms from yeast to flies. In contrast to the lifespan extension effect in lower organisms, it has been reported that overexpression of unc-51-like kinase 3 (ULK3), the mammalian homolog of autophagy-specific gene 1 (ATG1), induces premature senescence in human fibroblasts. Therefore, we asses...
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ژورنال
عنوان ژورنال: AGE
سال: 2011
ISSN: 0161-9152,1574-4647
DOI: 10.1007/s11357-011-9276-7